Leucocyte migration inhibition in liver disease

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Leucocyte migration inhibition in liver disease.

Clinical and histological features provide evidence that immunological reactions of the cell-mediated type are abnormal in some forms of chronic liver disease. By using the leucocyte migration test of Søborg and Bendixen (1967), a correlate of cellular hypersensitivity in vitro, the authors studied the production of the migration inhibitory factor by lymphocytes exposed to a fetal liver homogen...

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Results of the direct leucocyte migration inhibition (LMI) test using gluten fraction III as antigen were unaffected by incorporation of puromycin into the culture medium at concentrations shown to prevent lymphokine mediated inhibition. Results of the LMI test performed with purified polymorphs were similar to and correlated with results of the standard LMI test using mixed leucocytes in both ...

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Leucocyte migration inhibition test in cases of ischaemic heart disease.

Cases of ischaemic heart disease have been studied for the cell-mediated immune response against human heart antigen by using the leucocyte migration inhibition test. In 30 cases of acute myocardial infarction, the leucocyte migration inhibition values started increasing from the first week reaching a peak in 3 to 4 weeks and then declining but still above control values 12 months after infarct...

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Leucocyte migration inhibition by heart extract and liver mitochondria in patients with myocardial infarction.

Leucocyte migration inhibition by heart extract and mitochondria can be shown in patients with myocardial infarction and angina. The active constituent of the heart extract in the nmgration test resides in the mitochondrial fraction. Migration inhibition by mitochondria is also seen in postoperative patients and subjects with a variety of autoimmune diseases, and seems to be a sensitive index o...

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Reduced leucocyte zinc in liver disease.

The zinc content of peripheral blood leucocytes has been measured in normal controls and in three groups of patients with liver disease. A significant reduction in leucocyte zinc, but not erythrocyte zinc, was observed in patients with primary biliary cirrhosis, alcoholic cirrhosis, and active chronic hepatitis. It is suggested that the nucleated tissues of some patients with liver disease are ...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1974

ISSN: 0021-9746

DOI: 10.1136/jcp.27.10.772